Human Biology & BioImaging
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Qin W, Ugur E, Mulholland CB, Bultmann S, Solovei I, Modic M, Smets M, Wierer M, Forné I, Imhof A, Cardoso MC and Leonhardt H (2021). Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency. Nucleic Acids Res., 49, 7406-7423. PubMed

Kempf JM, Weser S, Bartoschek MD, Metzeler KH, Vick B, Herold T, Völse K, Mattes R, Scholz M, Wange LE, Festini M, Ugur E, Roas M, Weigert O, Bultmann S, Leonhardt H, Schotta G, Hiddemann W, Jeremias I and Spiekermann K (2021). Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML. Sci Rep., 11, 5838. PubMed

Bartoschek MD, Ugur E, Nguyen TA, Rodschinka G, Wierer M, Lang K and Bultmann S (2021). Identification of permissive amber suppression sites for efficient non-canonical amino acid incorporation in mammalian cells. Nucleic Acids Res., 2021 Mar 3. PubMed

Petryk N, Bultmann S, Bartke T and Defossez PA (2020). Staying true to yourself: mechanisms of DNA methylation maintenance in mammals. Nucleic Acids Res., 49, 3020-3032. PubMed

Gavins GC, Gröger K, Bartoschek MD, Wolf P, Beck-Sickinger AG, Bultmann S and Seitz O (2020). Live cell PNA labelling enables erasable fluorescence imaging of membrane proteins. Nat Chem., 13, 15-23. PubMed

Mulholland CB, Nishiyama A, Ryan J, Nakamura R, Yiğit M, Glück IM, Trummer C, Qin W, Bartoschek MD, Traube FR, Parsa E, Ugur E, Modic M, Acharya A, Stolz P, Ziegenhain C, Wierer M, Enard W, Carell T, Lamb DC, Takeda H, Nakanishi M, Bultmann S and Leonhardt H (2020). Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nat Commun., 11, 5972. PubMed

Ignatova VV, Kaiser S, Ho JSY, Bing X, Stolz P, Tan XY, Lee CL, Gay FPH, Lastres PR, Gerlini R, Rathkolb B, Aguilar-Pimentel A, Sanz-Moreno A, Klein-Rodewald T, Calzada-Wack J, Ibragimov E, Valenta M, Lukauskas S, Pavesi A , Marschall S, Leuchtenberger S, Fuchs H, Gailus-Durner V, de Angelis MH, Bultmann S, Rando OJ, Guccione E, Kellner SM and Schneider R (2020). METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth. Sci Adv., 6: eaaz4551. PubMed

Mulholland CB, Traube FR, Ugur E, Parsa E, Eckl EM, Schönung M, Modic M, Bartoschek MD, Stolz P, Ryan J, Carell T, Leonhardt H and Bultmann S (2020). Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency. Sci. Rep., 10, 12066. PubMed

Bararia D, Hildebrand JA, Stolz S, Haebe S, Alig S, Trevisani CP, Osorio-Barrios F, Bartoschek MD, Mentz M, Pastore A, Gaitzsch E, Heide M, Jurinovic V, Rautter K, Gunawardana J, Sabdia M, Szczepanowski M, Richter J, Klapper W, Louissaint A Jr, Ludwig C, Bultmann S, Leonhardt H, Eustermann S, Hopfner KP, Hiddemann W, von Bergwelt-Baildon M, Steid C, Kridel R, Tobin JWD, Gandhi MK, Weinstock DM, Schmidt-Supprian M, Sárosi MB, Rudelius M, Passerini V, Mautner J and Weigert O (2020). Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma. Cell Rep., 31, 107522. PubMed

Ignatova VV, Stolz P, Kaiser S, Gustafsson TH, Lastres PR, Sanz-Moreno A, Cho YL, Amarie OV, Aguilar-Pimentel A, Klein-Rodewald T, Calzada-Wack J, Becker L, Marschall S, Kraiger M, Garrett L, Seisenberger C, Hölter SM, Borland K, Van De Logt E, Jansen PWTC, Baltissen MP, Valenta M, Vermeulen M, Wurst W, Gailus-Durner V, Fuchs H, de Angelis MH, Rando OJ, Kellner SM, Bultmann S and Schneider R (2020). The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs. Genes Dev., 34, 715-729. PubMed

Nishiyama A, Mulholland CB, Bultmann S, Kori S, Endo A, Saeki Y, Qin W, Trummer C, Chiba Y, Yokoyama H, Kumamoto S, Kawakami T, Hojo H, Nagae G, Aburatani H, Tanaka K, Arita K, Leonhardt H and Nakanishi M (2020). Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nat Commun., 11, 1222. PubMed

Stief S, Hanneforth AL, Weser S, Mattes R, Carlet M, Liu WH, Bartoschek MD, Domínguez Moreno H, Oettle M, Kempf J, Vick B, Ksienzyk B, Tizazu B, Rothenberg-Thurley M, Quentmeier H, Hiddemann W, Vosberg S, Greif PA, Metzeler KH, Schotta G, Bultmann S, Jeremias I, Leonhardt H and Spiekermann K (2020). Loss of KDM6A confers drug resistance in acute myeloid leukemia. Leukemia, 34, 50–62. PubMed

Götzl JK, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo AV, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, Bartenstein P, Rominger A, Tahirovic S, Smith ST, Madore C, Butovsky O, Capell A and Haass C (2019).Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO Mol Med., 11, e9711. PubMed

Foster BM, Stolz P, Mulholland CB, Montoya A, Kramer H, Bultmann S and Bartke T (2018). Critical Role of the UBL Domain in Stimulating the E3 Ubiquitin Ligase Activity of UHRF1 toward Chromatin. Mol Cell, 72, 739-752.e9. PubMed

Gasparoni G, Bultmann S, Lutsik P, Kraus TFJ, Sordon S, Vlcek J, Dietinger V, Steinmaurer M, Haider M, Mulholland CB, Arzberger T, Roeber S, Riemenschneider M, Kretzschmar HA, Giese A, Leonhardt H and Walter J (2018). DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex. Epigenetics Chromatin, 2018 Jul 25. PubMed

Hinrichs A, Kessler B, Kurome M, Blutke A, Kemter E, Bernau M, Scholz AM, Rathkolb B, Renner S, Bultmann S, Leonhardt H, de Angelis MH, Nagashima H, Hoeflich A, Blum WF, Bidlingmaier M, Wanke R, Dahlhoff M and Wolf E (2018). Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver. Mol Metab., 11, 113-128. PubMed

Bultmann S and Stricker SH (2018). Entering the post-epigenomic age: back to epigenetics. Open Biol., 8, 180013. PubMed

Garz AK, Wolf S, Grath S, Gaidzik V, Habringer S, Vick B, Rudelius M, Ziegenhain C, Herold S, Weickert MT, Smets M, Peschel C, Oostendorp RAJ, Bultmann S, Jeremias I, Thiede C, Döhner K, Keller U and Götze KS (2017). Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in FLT3-ITD AML with concurrent epigenetic mutations. Oncotarget, 8, 108738-108759. PubMed

Karg E, Smets M, Ryan J, Forné I, Qin W, Mulholland CB, Kalideris G, Imhof A, Bultmann S and Leonhardt H (2017). Ubiquitome analysis reveals PCNA-associated factor 15 (PAF15) as a specific ubiquitination target of UHRF1 in embryonic stem cells. J Mol Biol., 429, 3814-3824. PubMed

Dahlhoff M, Gaborit N, Bultmann S, Leonhardt H, Yarden Y and Schneider MR (2017). CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes. FEBS J., 284, 3339-3349.PubMed

Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trümbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, Butovsky O and Haass C (2017). TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. EMBO Rep., 18, 1186-1198. PubMed

Anton T and Bultmann S (2017). Site-specific recruitment of epigenetic factors with a modular CRISPR/Cas system. Nucleus, 8, 279-286. PubMed

Sellou H, Lebeaupin T, Chapuis C, Smith R, Hegele A, Singh HR, Kozlowski M, Bultmann S, Ladurner AG, Timinszky G and Huet S (2016). The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage. Mol Biol Cell, 27, 3791-3799. PubMed

Mulholland CB, Smets M, Schmidtmann E, Leidescher S, Markaki Y, Hofweber M, Qin W, Manzo M, Kremmer E, Thanisch K, Bauer C, Rombaut P, Herzog F, Leonhardt H and Bultmann S (2015). A modular open platform for systematic functional studies under physiological conditions. Nucleic Acids Res., 43, e112. PubMed

Feodorova Y, Koch M, Bultmann S, Michalakis S and Solovei I (2015). Quick and reliable method for retina dissociation and separation of rod photoreceptor perikarya from adult mice. MethodsX, 2, 39-46. PubMed

Anton T, Bultmann S, Leonhardt H and Markaki Y (2014). Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system. Nucleus, 5, 163-172. PubMed

Thanisch K, Schneider K, Morbitzer R, Solovei I, Lahaye T, Bultmann S and Leonhardt H (2013). Targeting and tracing of specific DNA sequences with dTALEs in living cells. Nucleic Acids Res., 42(6): e38. PubMed

Bultmann S and Leonhardt H (2013). Fluorescence microscopy-based high-throughput screening for factors involved in gene silencing. Methods Mol Biol, 1042, 237-44. PubMed

Schmidt CS, Bultmann S, Meilinger D, Zacher B, Tresch A, Maier KC, Peter C, Martin DE, Leonhardt H and Spada F (2012). Global DNA Hypomethylation Prevents Consolidation of Differentiation Programs and Allows Reversion to the Embryonic Stem Cell State. PLoS One, 2012 Dec 27, e52629. PubMed

Bultmann S, Morbitzer R, Schmidt CS, Thanisch K, Spada F, Elsaesser J, Lahaye T and Leonhardt H (2012). Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers. Nucleic Acids Res., 40, 5368-77. PubMed

Frauer C, Hoffmann T, Bultmann S, Casa V, Cardoso MC, Antes I and Leonhardt H (2011). Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain. PLoS ONE, 6, e21306. PubMed

Konstandin N, Bultmann S, Szwagierczak A, Dufour A, Ksienzyk B, Schneider F, Herold T, Mulaw M, Kakadia PM, Schneider S, Spiekermann K, Leonhardt H and Bohlander SK (2011). Genomic 5-hydroxymethylcytosine levels correlate with TET2 and IDH2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia. Leukemia, 25, 1649-52. PubMed

Szwagierczak A, Brachmann A, Schmidt CS, Bultmann S, Leonhardt H and Spada F (2011). Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5 hydroxymethylcytosine. Nucl. Acids Res., 39, 5149-56. PubMed

Frauer C, Rottach A, Meilinger D, Bultmann S, Fellinger K, Hasenöder S, Wang M, Qin W, Söding J, Spada F and Leonhardt H (2011). Different Binding Properties and Function of CXXC Zinc Finger Domains in Dnmt1 and Tet1. PLoS ONE, 6, e16627. PubMed

Szwagierczak A, Bultmann S, Schmidt CS, Spada F and Leonhardt H (2010). Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA. Nucl. Acids Res., 38, e181. PubMed

Meilinger D, Fellinger K, Bultmann S, Rothbauer U, Bonapace IM, Klinkert WE, Spada F and Leonhardt H (2009). Np95 interacts with de novo DNA methyltransferases Dnmt3a and 3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO Reports, 10, 1259-64. PubMed