Human Biology & BioImaging

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Epigenetic mechanisms control cell-, tissue-, and development-specific gene expression. We study the basic epigenetic mechanisms involved in pluripotency, development and disease. We use a broad spectrum of methods centered around the application of advanced light microscopy to study protein dynamics, protein-protein interactions, and subcellular localization in live and fixed cells. In combination with genetic, biochemical, and biophysical approaches we aim to better understand the epigenetic pathways controlling embryonic development and the defects leading to cancer formation.