Human Biology & BioImaging

Breadcrumb Navigation



2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 and earlier

Bachem K, Li X, Ceolin S, Mühling B, Hörl D, Harz H, Leonhardt H, Arnoult L, Weber S, Matarlo B, Prud'homme B and Gompel N (2024). Regulatory evolution tuning pigmentation intensity quantitatively in Drosophila. Sci Adv., 10, eadl2616. PubMed

Palikyras S, Sofiadis K, Stavropoulou A, Danieli-Mackay A, Varamogianni-Mamatsi V, Hörl D, Nasiscionyte S, Zhu Y, Papadionysiou I, Papadakis A, Josipovic N, Zirkel A, O'Connell A, Loughran G, Keane J, Michel A, Wagner W, Beyer A, Harz H, Leonhardt H, Lukinavicius G, Nikolaou C and Papantonis A (2024). Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor. Aging Cell, 9, e14083. PubMed


Pabba MK, Ritter C, Chagin VO, Meyer J, Celikay K, Stear JH, Loerke D, Kolobynina K, Prorok P, Schmid AK, Leonhardt H, Rohr K and Cardoso MC (2023). Replisome loading reduces chromatin motion independent of DNA synthesis. Elife, 12, RP87572. PubMed

Ullrich S, Leidescher S, Feodorova Y, Thanisch K, Fini JB, Kaspers B, Weber F, Markova B, Fuehrer D, Romitti M, Krebs S, Blum H, Leonhardt H, Costagliola S, Heuer H and Solovei I (2023). The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes. Front. Cell Dev. Biol., 11, 1265407. PubMed

Ziegler KA, Ahles A, Dueck A, Esfandyari D, Pichler P, Weber K, Kotschi S, Bartelt A, Sinicina I, Graw M, Leonhardt H, Weckbach LT, Massberg S, Schifferer M, Simons M, Hoeher L, Luo J, Ertürk A, Schiattarella GG, Sassi Y, Misgeld T and Engelhardt S (2023). Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease. Science, 381, 285-290. PubMed

Nixdorf D, Sponheimer M, Berghammer D, Engert F, Bader U, Philipp N, Kazerani M, Straub T, Rohrbacher L, Wange L, Dapa S, Atar D, Seitz CM, Brandstetter K, Linder A, von Bergwelt M, Leonhardt H, Mittelstaet J, Kaiser A, Bücklein V and Subklewe M (2023). Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML. Leukemia, 37, 1298-1310. PubMed LMU News

Ugur E, de la Porte A, Qin W, Bultmann S, Ivanova A, Drukker M, Mann M, Wierer M and Leonhardt H (2023). Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components. Nucleic Acids Res., 51, 2671-2690. PubMed

Miyashita R, Nishiyama A, Qin W, Chiba Y, Kori S, Kato N, Konishi C, Kumamoto S, Kozuka-Hata H, Oyama M, Kawasoe Y, Tsurimoto T, Takahashi TS, Leonhardt H, Arita K and Nakanishi M (2023). The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5. Elife, 12, e79013. PubMed

Zhang H, Qin W, Romero H, Leonhardt H and Cardoso MC (2023). Heterochromatin organization and phase separation. Nucleus, 14, 2159142. PubMed



Hata K, Kobayashi N, Sugimura K, Qin W, Haxholli D, Chiba Y, Yoshimi S, Hayashi G, Onoda H, Ikegami T, Mulholland CB, Nishiyama A, Nakanishi M, Leonhardt H, Konuma T and Arita K (2022). Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger. Nucleic Acids Res., 50, 12527-12542. PubMed

Schmacke NA, O'Duill F, Gaidt MM, Szymanska I, Kamper JM, Schmid-Burgk JL, Mädler SC, Mackens-Kiani T, Kozaki T, Chauhan D, Nagl D, Stafford CA, Harz H, Fröhlich AL, Pinci F, Ginhoux F, Beckmann R, Mann M, Leonhardt H and Hornung V (2022). IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network. Immunity, 55, 2271-2284.e7. PubMed

Qin W, Steinek C, Kolobynina K, Forné I, Imhof A, Cardoso MC and Leonhardt H (2022). Probing protein ubiquitination in live cells. Nucleic Acids Res., 50, e125. PubMed

Wang Z, Fan R, Russo A, Cernilogar FM, Nuber A, Schirge S, Shcherbakova I, Dzhilyanova I, Ugur E, Anton T, Richter L, Leonhardt H, Lickert H and Schotta G (2022). Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm. Nat Commun., 13, 5447. PubMed

Roas M, Vick B, Kasper MA, Able M, Polzer H, Gerlach M, Kremmer E, Hecker JS, Schmitt S, Stengl A, Waller V, Hohmann N, Festini M, Ludwig AE, Rohrbacher L, Herold T, Subklewe M, Götze KS, Hackenberger CPR, Schumacher D, Helma-Smets J, Jeremias I, Leonhardt H and Spiekermann K (2022). Targeting FLT3 by new-generation antibody-drug-conjugate in combination with kinase inhibitors for treatment of AML. Blood, 141, 1023-1035. PubMed

Stolz P, Mantero AS, Tvardovskiy A, Ugur E, Wange LE, Mulholland CB, Cheng Y, Wierer M, Enard W, Schneider R, Bartke T, Leonhardt H, Elsässer SJ and Bultmann S (2022). TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation. Nucleic Acids Res.,  50, 8491-8511. PubMed

Leidescher S, Ribisel J, Ullrich S, Feodorova Y, Hildebrand E, Galitsyna A, Bultmann S, Link S, Thanisch K, Mulholland C, Dekker J, Leonhardt H, Mirny L and Solovei I (2022). Spatial organization of transcribed eukaryotic genes. Nat Cell Biol., 24, 327-339. PubMed

Zhang L, Isselstein M, Köhler J, Eleftheriadis N, Huisjes N, Guirao M, Narducci A, Smit J, Stoffels J, Harz H, Leonhardt H, Herrmann A and Cordes T (2022). Linker Molecules Convert Commercial Fluorophores into Tailored Functional Probes during Bio-labeling. Angew Chem Int Ed Engl., 61, e202112959. PubMed

Brandstetter K, Zülske T, Ragoczy T, Hörl D, Guirao-Ortiz M, Steinek C, Barnes T, Stumberger G, Schwach J, Haugen E, Rynes E, Korber P, Stamatoyannopoulos JA, Leonhardt H, Wedemann G and Harz H (2022). Differences in nanoscale organization of regulatory active and inactive human chromatin. Biophys J., 121, 977-990. PubMed

Zhang H, Romero H, Schmidt A, Gagova K, Qin W, Bertulat B, Lehmkuhl A, Milden M, Eck M, Meckel T, Leonhardt H and Cardoso MC (2022). MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid–liquid phase separation and restricted by DNA methylation. Nucleus, 13, 1-34. PubMed



Landspersky T, Saçma M, Rivière J, Hecker JS, Hettler F, Hameister E, Brandstetter K, Istvanffy R, Romero Marquez S, Ludwig R, Götz M, Buck MC, Wolf M, Schiemann M, Ruland J, Strunk D, Shimamura A, Myers KC, Yamaguchi TP, Kieslinger M, Leonhardt H, Bassermann F, Götze KS, Geiger H, Schreck C and Oostendorp RAJ (2021). Autophagy In Mesenchymal Progenitors Protects Mice Against Bone Marrow Failure After Severe Intermittent Stress. Blood, 139, 690-703. PubMed

Jakubke C, Roussou R, Maiser A, Schug C, Thoma F, Bunk D, Hörl D, Leonhardt H, Walter P, Klecker T and Osman C (2021). Cristae-dependent quality control of the mitochondrial genome. Sci Adv., 7, eabi8886. PubMed

Duan N, Arroyo M, Deng W, Cardoso MC and Leonhardt H (2021). Visualization and characterization of RNA-protein interactions in living cells. Nucleic Acids Res., 49, e107. PubMed

Qin W, Ugur E, Mulholland CB, Bultmann S, Solovei I, Modic M, Smets M, Wierer M, Forné I, Imhof A, Cardoso MC and Leonhardt H (2021). Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency. Nucleic Acids Res., 49, 7406-7423. PubMed

Lei J, Ma-Lauer Y, Han Y, Thoms M, Buschauer R, Jores J, Thiel V, Beckmann R, Deng W, Leonhardt H, Hilgenfeld R and von Brunn A (2021). The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation. EMBO J., 40, e102277. PubMed

Schwach J, Kolobynina K, Brandstetter K, Gerlach M, Ochtrop P, Helma J, Hackenberger CPR, Harz H, Cardoso MC, Leonhardt H and Stengl A (2021). Site-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy. Chembiochem., 22, 1205-1209. PubMed

Kempf JM, Weser S, Bartoschek MD, Metzeler KH, Vick B, Herold T, Völse K, Mattes R, Scholz M, Wange LE, Festini M, Ugur E, Roas M, Weigert O, Bultmann S, Leonhardt H, Schotta G, Hiddemann W, Jeremias I and Spiekermann K (2021). Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML. Sci Rep., 11, 5838. PubMed

Levone BR, Lenzken SC, Antonaci M, Maiser A, Rapp A, Conte F, Reber S, Mechtersheimer J, Ronchi AE, Mühlemann O, Leonhardt H, Cardoso MC, Ruepp MD and Barabino SML (2021). FUS-dependent liquid-liquid phase separation is important for DNA repair initiation. J Cell Biol., 220, e202008030. PubMed

Qin W, Stengl A, Ugur E, Leidescher S, Ryan J, Cardoso MC and Leonhardt H (2021). HP1β carries an acidic linker domain and requires H3K9me3 for phase separation. Nucleus, 12, 44-57. PubMed



Le Poul Y, Xin Y, Ling L, Mühling B, Jaenichen R, Hörl D, Bunk D, Harz H, Leonhardt H, Wang Y, Osipova E, Museridze M, Dharmadhikari D, Murphy E, Rohs R, Preibisch S, Prud’homme B and Gompel N (2020). Regulatory encoding of quantitative variation in spatial activity of a Drosophila enhancer. Sci. Adv., 6, eabe2955. PubMed

Rausch C, Weber P, Prorok P, Hörl D, Maiser A, Lehmkuhl A, Chagin V, Casas-Delucchi CS, Leonhardt H and Cardoso MC (2020). Developmental differences in genome replication program and origin activation. Nucleic Acids Res., 48, 12751-12777. PubMed

Cremer M, Brandstetter K, Maiser A, Rao SSP, Schmid VJ, Guirao-Ortiz M, Mitra N, Mamberti S, Klein KN, Gilbert DM, Leonhardt H, Cardoso MC, Lieberman Aiden E, Harz H and Cremer T (2020). Cohesin depleted cells rebuild functional nuclear compartments after endomitosis. Nat Commun., 11, 6146. PubMed

Mulholland CB, Nishiyama A, Ryan J, Nakamura R, Yiğit M, Glück IM, Trummer C, Qin W, Bartoschek MD, Traube FR, Parsa E, Ugur E, Modic M, Acharya A, Stolz P, Ziegenhain C, Wierer M, Enard W, Carell T, Lamb DC, Takeda H, Nakanishi M, Bultmann S and Leonhardt H (2020). Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nat Commun., 11, 5972. PubMed

Schmitt S, Tahk S, Lohner A, Hänel G, Maiser A, Hauke M, Patel L, Rothe M, Josenhans C, Leonhardt H, Griffioen M, Deiser K, Fenn NC, Hopfner KP and Subklewe M (2020). Fusion of bacterial flagellin to a dendritic cell-targeting αCD40 antibody construct coupled with viral or leukemia-specific antigens enhances dendritic cell maturation and activates peptide-responsive T cells. Frontiers in Immunology, 11, 602802. PubMed

Pandya-Jones A, Markaki Y, Serizay J, Chitiashvilli T, Mancia Leon WR, Damianov A, Chronis C, Papp B, Chen CK, McKee R, Wang XJ, Chau A, Sabri S, Leonhardt H, Zheng S, Guttman M, Black DL and Plath K (2020). A protein assembly mediates Xist localization and gene silencing. Nature, 587, 145-151. PubMed

Mulholland CB, Traube FR, Ugur E, Parsa E, Eckl EM, Schönung M, Modic M, Bartoschek MD, Stolz P, Ryan J, Carell T, Leonhardt H and Bultmann S (2020). Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency. Sci. Rep., 10, 12066. PubMed

Ugur E, Bartoschek MD and Leonhardt H (2020). Locus-Specific Chromatin Proteome Revealed by Mass Spectrometry-Based CasID. Methods Mol Biol., 2175, 109-121. PubMed

Maiser A, Dillinger S, Längst G, Schermelleh L, Leonhardt H and Németh A (2020). Super-resolution in situ analysis of active ribosomal DNA chromatin organization in the nucleolus. Sci Rep., 10, 7462. PubMed

Bararia D, Hildebrand JA, Stolz S, Haebe S, Alig S, Trevisani CP, Osorio-Barrios F, Bartoschek MD, Mentz M, Pastore A, Gaitzsch E, Heide M, Jurinovic V, Rautter K, Gunawardana J, Sabdia M, Szczepanowski M, Richter J, Klapper W, Louissaint A Jr, Ludwig C, Bultmann S, Leonhardt H, Eustermann S, Hopfner KP, Hiddemann W, von Bergwelt-Baildon M, Steid C, Kridel R, Tobin JWD, Gandhi MK, Weinstock DM, Schmidt-Supprian M, Sárosi MB, Rudelius M, Passerini V, Mautner J and Weigert O (2020). Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma. Cell Rep., 31, 107522. PubMed

Nishiyama A, Mulholland CB, Bultmann S, Kori S, Endo A, Saeki Y, Qin W, Trummer C, Chiba Y, Yokoyama H, Kumamoto S, Kawakami T, Hojo H, Nagae G, Aburatani H, Tanaka K, Arita K, Leonhardt H and Nakanishi M (2020). Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nat Commun., 11, 1222. PubMed

Schneider M, Trummer C, Stengl A, Zhang P, Szwagierczak A, Cardoso MC, Leonhardt H, Bauer C and Antes I (2020). Systematic analysis of the binding behaviour of UHRF1 towards different methyl- and carboxylcytosine modification patterns at CpG dyads. PLoS One, 15, e0229144. PubMed

Deng W, Bates JA, Wei H, Bartoschek MD, Conradt B and Leonhardt H (2020). Tunable light and drug induced depletion of target proteins. Nat Commun., 11, 304. PubMed LMU News

Stief S, Hanneforth AL, Weser S, Mattes R, Carlet M, Liu WH, Bartoschek MD, Domínguez Moreno H, Oettle M, Kempf J, Vick B, Ksienzyk B, Tizazu B, Rothenberg-Thurley M, Quentmeier H, Hiddemann W, Vosberg S, Greif PA, Metzeler KH, Schotta G, Bultmann S, Jeremias I, Leonhardt H and Spiekermann K (2020). Loss of KDM6A confers drug resistance in acute myeloid leukemia. Leukemia, 34, 50–62. PubMed

Kasper MA, Gerlach M, Schneider AFL, Groneberg C, Ochtrop P, Boldt S, Schumacher D, Helma J, Leonhardt H, Christmann M and Hackenberger C (2020). NHS-modified ethynylphosphonamidates enable the synthesis of configurationally defined protein conjugates. Chembiochem., 21, 113-119. PubMed


Chagin VO, Reinhart B, Becker A, Mortusewicz O, Jost KL, Rapp A, Leonhardt H and Cardoso MC (2019). Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair. Nucleus, 10, 231-253. PubMed

Wagner A, Hofmeister O, Rolland SG, Maiser A, Aasumets K, Schmitt S, Schorpp K, Feuchtinger A, Hadian K, Schneider S, Zischka H, Leonhardt H, Conradt B, Gerhold JM and Wolf A (2019). Mitochondrial Alkbh1 localises to mtRNA granules and its knockdown induces mitochondrial UPR in humans and C. elegans. J. Cell Sci.,132, 19. PubMed

Hörl D, Rojas Rusak F, Preusser F, Tillberg P, Randel N, Chhetri RK, Cardona A, Keller PJ, Harz H, Leonhardt H, Treier M and Preibisch S (2019). BigStitcher: Reconstructing high-resolution image datasets of cleared and expanded samples. Nature Methods, 16, 870-874. PubMed

Mahamid J, Tegunov D, Maiser A, Arnold J, Leonhardt H, Plitzko JM and Baumeister W (2019). Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association. Proc Natl Acad Sci U S A, 116, 16866-16871. PubMed

Schumacher D, Leonhardt H, Hackenberger CPR and Helma J (2019). One-Step Fluorescent Protein Labeling by Tubulin Tyrosine Ligase. Methods Mol Biol., 2033, 167-189. PubMed

Chiasson D, Giménez-Oya V, Bircheneder M, Bachmaier S, Studtrucker T, Ryan J, Sollweck K, Leonhardt H, Boshart M, Dietrich P and Parniske M (2019). A unified multi-kingdom Golden Gate cloning platform. Sci Rep, 9, 10131. PubMed

Kasper MA, Stengl A, Ochtrop P, Gerlach M, Stoschek T, Schumacher D, Helma J, Penkert M, Krause E, Leonhardt H and Hackenberger C (2019). Ethynylphosphonamidates for the rapid and cysteine selective generation of efficacious Antibody-Drug-Conjugates. Angew Chem Int Ed Engl., 58, 11631-11636. PubMed

Falk M, Feodorova Y, Naumova N, Imakaev M, Lajoie BR, Leonhardt H, Joffe B, Dekker J, Fudenberg G, Solovei I and Mirny LA (2019). Heterochromatin drives compartmentalization of inverted and conventional nuclei. Nature, 570, 395-399. [Epub ahead of print] PubMed

Gerlach M, Stoschek T, Leonhardt H, Hackenberger CPR, Schumacher D and Helma J (2019). Tubulin Tyrosine Ligase-Mediated Modification of Proteins. Methods Mol Biol., 2012, 327-355. PubMed

Tepper S, Mortusewicz O, Czlonka E, Bello A, Schmidt A. Jeschke J, Fischbach A, Pfeil I, Petersen-Mahrt SK, Mangerich A, Helleday T, Leonhardt H and Jungnickel B (2019). Restriction of AID activity and somatic hypermutation by PARP-1. Nucleic Acids Res., 47, 7418-7429. PubMed

Stengl A, Gerlach M, Kasper MA, Hackenberger CPR, Leonhardt H, Schumacher D, and Helma J (2019). TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles. Org Biomol Chem., 17, 4964-4969.  PubMed

Kasper MA, Glanz M, Stengl A, Penkert M, Klenk S, Sauer T, Schumacher D, Helma J, Krause E, Cardoso MC, Leonhardt H and Hackenberger C (2019). Cysteine-selective phosphonamidate electrophiles for modular protein bioconjugations. Angew Chem Int Ed Engl., 58, 11625-11630. PubMed

Effenberger M, Stengl A, Schober K, Gerget M, Kampick M, Müller TR, Schumacher D, Helma J, Leonhardt H and Busch DH (2019). FLEXamers: A Double Tag for Universal Generation of Versatile Peptide-MHC Multimers. J Immunol., 202, 2164-2171. PubMed


Wenk C, Garz AK, Grath S, Huberle C, Witham D, Weickert M, Malinverni R, Niggemeyer J, Kyncl M, Hecker J, Pagel C, Mulholland CB, Müller-Thomas C, Leonhardt H, Bassermann F, Oostendorp RAJ, Metzeler KH, Buschbeck M and Götze KS (2018). Direct modulation of the bone marrow mesenchymal stromal cell compartment by azacitidine enhances healthy hematopoiesis. Blood Adv., 2, 3447-3461. PubMed

Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, Vollmer A, Markaki Y, Leonhardt H, Buske C, Lipka DB, Plass C, Zheng Y, Mulaw MA, Geiger H and Florian MC (2018). LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome Biol., 19, 189.PubMed

Chiu HY, Bates JA, Helma J, Engelke H, Harz H, Bein T and Leonhardt H (2018). Nanoparticle Mediated Delivery and Small Molecule Triggered Activation of Proteins in the Nucleus. Nucleus, 9, 530-542. PubMed

Gasparoni G, Bultmann S, Lutsik P, Kraus TFJ, Sordon S, Vlcek J, Dietinger V, Steinmaurer M, Haider M, Mulholland CB, Arzberger T, Roeber S, Riemenschneider M, Kretzschmar HA, Giese A, Leonhardt H and Walter J (2018). DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex. Epigenetics Chromatin, 2018 Jul 25. PubMed

Hinrichs A, Kessler B, Kurome M, Blutke A, Kemter E, Bernau M, Scholz AM, Rathkolb B, Renner S, Bultmann S, Leonhardt H, de Angelis MH, Nagashima H, Hoeflich A, Blum WF, Bidlingmaier M, Wanke R, Dahlhoff M and Wolf E (2018). Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver. Mol Metab., 11, 113-128.  PubMed

Feldmann DP, Cheng Y, Kandil R, Xie Y, Mohammadi M, Harz H, Sharma A, Peeler DJ, Moszczynska A, Leonhardt H, Pun SH and Merkel OM (2018). In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells. J Control Release, 276, 50-58.  PubMed

Schumacher D, Helma J, Schneider AFL, Leonhardt H and Hackenberger CPR (2018). Nanobodies: Chemical Functionalization Strategies and Intracellular Applications. Angew Chem Int Ed Engl., 57, 2314-2333. PubMed

Reiter K, Polzer H, Krupka C, Maiser A, Vick B, Rothenberg-Thurley M, Metzeler KH, Dörfel D, Salih HR, Jung G, Nößner E, Jeremias I, Hiddemann W, Leonhardt H, Spiekermann K, Subklewe M and Greif PA (2018). Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia. Leukemia, 32, 313-322. PubMed

Helma J, Leonhardt H, Hackenberger CPR and Schumacher D (2018). Tub-Tag Labeling; Chemoenzymatic Incorporation of Unnatural Amino Acids. Methods Mol Biol., 1728, 67-93. PubMed

Schumacher D, Helma-Smets J, Hackenberger C and Leonhardt H (2018). Neue Generation von Antikörper-Wirkstoff-Konjugaten. Chem. Unserer Zeit, 52, 80-83.

Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D and Heissmeyer V (2018). Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. Nat Commun, 9, 299. PubMed 



Essig K, Hu D, Guimaraes JC, Alterauge D, Edelmann S, Raj T, Kranich J, Behrens G, Heiseke A, Floess S, Klein J, Maiser A, Marschall S, Hrabĕ de Angelis M, Leonhardt H, Calkhoven CF, Noessner E, Brocker T, Huehn J, Krug AB, Zavolan M, Baumjohann D and Heissmeyer V (2017). Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells. Immunity, 47, 1067-1082.e12 PubMed

Karg E, Smets M, Ryan J, Forné I, Qin W, Mulholland CB, Kalideris G, Imhof A, Bultmann S and Leonhardt H (2017). Ubiquitome analysis reveals PCNA-associated factor 15 (PAF15) as a specific ubiquitination target of UHRF1 in embryonic stem cells. J Mol Biol., 429, 3814-3824.PubMed

Gressel S, Schwalb B, Decker TM, Qin W, Leonhardt H, Eick D and Cramer P (2017). CDK9-dependent RNA polymerase II pausing controls transcription initiation. eLife, 6, e29736. PubMed

Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V and Hopfner KP (2017). cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders. Nature, 549, 394-398. PubMed

Dahlhoff M, Gaborit N, Bultmann S, Leonhardt H, Yarden Y and Schneider MR (2017). CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes. FEBS J., 284, 3339-3349. PubMed

Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y and Defossez PA (2017). Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation. Mol Cell, 67, 550-565.e5. PubMed

Cremer M, Schmid VJ, Kraus F, Markaki Y, Hellmann I, Maiser A, Leonhardt H, John S, Stamatoyannopoulos J and Cremer T (2017). Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters. Epigenetics Chromatin, 10, 39. PubMed

Ungewiß H, Vielmuth F, Suzuki ST, Maiser A, Harz H, Leonhardt H, Kugelmann D, Schlegel N and Waschke J (2017). Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase. Sci Rep., 7, 6329. PubMed

Herce HD, Schumacher D, Schneider AFL, Ludwig AK, Mann FA, Fillies M, Kasper MA, Reinke S, Krause E, Leonhardt H, Cardoso MC and Hackenberger CPR (2017). Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells. Nat Chem, 9, 762-771. PubMed

Pünzeler S, Link S, Wagner G, Keilhauer EC, Kronbeck N, Spitzer RM, Leidescher S, Markaki Y, Mentele E, Regnard C, Schneider K, Takahashi D, Kusakabe M, Vardabasso C, Zink LM, Straub T, Bernstein E, Harata M, Leonhardt H, Mann M, Rupp RA, and Hake SB (2017). Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation. EMBO J., 36, 2263-2279. PubMed

Natale F, Rapp A, Yu W, Maiser A, Harz H, Scholl A, Grulich S, Anton T, Hörl D, Chen W, Durante M, Taucher-Scholz G, Leonhardt H and Cardoso MC (2017). Identification of the elementary structural units of the DNA damage response. Nat Commun., 8, 15760. PubMed

Schlenker R, Olguín-Contreras LF, Leisegang M, Schnappinger J, Disovic A, Rühland S, Nelson PJ, Leonhardt H, Harz H, Wilde S, Schendel DJ, Uckert W, Willimsky G and Noessner E (2017). Chimeric PD-1:28 receptor upgrades low-avidity T cells and restores effector function of tumor-infiltrating lymphocytes for adoptive cell therapy. Cancer Res., 77, 3577-3590. PubMed

Chiu HY, Leonhardt H and Bein T (2017). Synthesis and Functionalization of Ordered Large-Pore Mesoporous Silica Nanoparticles for Biomedical Applications. Chem. Ing. Tech., 89, 876-886.

Zhang P, Ludwig AK, Hastert FD, Rausch C, Lehmkuhl A, Hellmann I, Smets M, Leonhardt H and Cardoso MC (2017). L1 retrotransposition is activated by Ten-eleven-translocation protein 1 and repressed by methyl-CpG binding proteins. Nucleus, 8, 548-562. PubMed

Schumacher D, Lemke O, Helma J, Gerszonowicz L, Waller V, Stoschek T, Durkin PM, Budisa N, Leonhardt H, Keller BG and Hackenberger CPR (2017). Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling. Chem. Sci., 8, 3471-3478. PubMed

Kraus F, Miron E, Demmerle J, Chitiashvili T, Budco A, Alle Q, Matsuda A, Leonhardt H, Schermelleh L and Markaki Y (2017). Quantitative 3D structured illumination microscopy of nuclear structures. Nat Protoc, 12, 1011-1028. PubMed

van de Werken HJ, de Haan JC, Feodorova Y, Bijos D, Weuts A, Theunis K, Holwerda S, Meuleman W, Pagie L, Thanisch K, Kumar P, Leonhardt H, Marynen P, van Steensel B, Voet T, de Laat W, Solovei I and Joffe B (2017). Small chromosomal regions position themselves autonomously according to their chromatin class. Genome Res., 27, 922-933. PubMed

Smets M, Link S, Wolf P, Schneider K, Solis V, Ryan J, Meilinger D, Qin W and Leonhardt H (2017). DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation. Hum. Mol. Genet., 26, 1522-1534. PubMed

Schueder F, Strauss MT, Hoerl D, Schnitzbauer J, Schlichthaerle T, Strauss S, Yin P, Harz H, Leonhardt H and Jungmann R (2017). Universal Super-Resolution Multiplexing by DNA Exchange. Angew Chem Int Ed Engl., 56, 4052-4055. PubMed

Ziegenhain C, Vieth B, Parekh S, Reinius B, Guillaumet-Adkins A, Smets M, Leonhardt H, Heyn H, Hellmann I and Enard W (2017). Comparative Analysis of Single-Cell RNA Sequencing Methods. Mol. Cell, 65, 631-643. PubMed

Borgel J, Tyl M, Schiller K, Pusztai Z, Dooley CM, Deng W, Wooding C, White RJ, Warnecke T, Leonhardt H, Busch-Nentwich EM and Bartke T (2017). KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1. Nucleic Acids Res., 45, 1114-1129. PubMed

Thanisch K, Song C, Engelkamp D, Koch J, Wang A, Hallberg E, Foisner R, Leonhardt H, Stewart CL, Joffe B and Solovei I (2017). Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering. Differentiation, 94, 58-70. PubMed

Stengl A, Hörl D, Leonhardt H and Helma J (2017). A Simple and Sensitive High-Content Assay for the Characterization of Antiproliferative Therapeutic Antibodies. SLAS Discov., 22, 309-315. PubMed

Röder R, Helma J, Preiß T, Rädler JO, Leonhardt H and Wagner E (2017). Intracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells. Pharm Res., 34, 161-174. PubMed




Ludwig AK, Zhang P, Hastert FD, Meyer S, Rausch C, Herce HD, Müller U, Lehmkuhl A, Hellmann I, Trummer C, Storm C, Leonhardt H and Cardoso MC (2016). Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise. Nucleic Acids Res., 45, 2438-2457. PubMed

Schmidtmann E, Anton T, Rombaut P, Herzog F and Leonhardt H (2016). Determination of Local Chromatin Composition by CasID. Nucleus, 7, 476-484. PubMed

Ma-Lauer Y, Carbajo-Lozoya J, Hein MY, Müller MA, Deng W, Lei J, Meyer B, Kusov Y, von Brunn B, Bairad DR, Hünten S, Drosten C, Hermeking H, Leonhardt H, Mann M, Hilgenfeld R and von Brunn A (2016). p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1. PNAS, 113, E5192-201. PubMed

Chiu HY, Deng W, Engelke H, Helma J, Leonhardt H and Bein T (2016). Intracellular chromobody delivery by mesoporous silica nanoparticles for antigen targeting and visualization in real time. Sci Rep., 6, 25019. PubMed

Anton T, Leonhardt H and Markaki Y (2016). Visualization of Genomic Loci in Living Cells with a Fluorescent CRISPR/Cas9 System. Methods Mol Biol., 1411, 407-17. PubMed

Crevenna AH, Blank B, Maiser A, Emin D, Prescher J, Beck G, Kienzle C, Bartnik K, Habermann B, Pakdel M, Leonhardt H, Lamb DC and von Blume J (2016). Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network. J Cell Biol., 213, 305-14. PubMed

Chagin VO, Casas-Delucchi CS, Reinhart M, Schermelleh L, Markaki Y, Maiser A, Bolius JJ, Bensimon A, Fillies M, Domaing P, Rozanov YM, Leonhardt H and Cardoso MC (2016). 4D Visualization of replication foci in mammalian cells corresponding to individual replicons. Nat Commun, 7, 11231. PubMed

Schumacher D, Hackenberger CP, Leonhardt H and Helma J (2016). Current Status: Site-Specific Antibody Drug Conjugates. J Clin Immunol., 2016 Mar 22. [Epub ahead of print] PubMed

Becker A, Zhang P, Allmann L, Meilinger D, Bertulat B, Eck D, Hofstaetter M, Bartolomei G, Hottiger M, Schreiber V, Leonhardt H and Cardoso MC (2016). Poly(ADP-ribosyl)ation of methyl CpG binding protein 2 regulates chromatin structure. J Biol Chem., 291, 4873-81. PubMed



Rajan M, Mortusewicz O, Rothbauer U, Hastert FD, Schmidthals K, Rapp A, Leonhardt H and Cardoso MC (2015). Generation of an alpaca-derived nanobody recognizing γ-H2AX. FEBS Open Bio., 5, 779-788. PDF, PubMed

Schumacher D, Helma J, Mann FA, Pichler G, Natale F, Krause E, Cardoso MC, Hackenberger CP and Leonhardt H (2015). Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase. Angew Chem Int Ed Engl., 54, 13787-91. PDF, PubMed

Klamecka K, Severin PM, Milles LF, Gaub HE and Leonhardt H (2015). Energy profile of nanobody-GFP complex under force. Phys. Biol., 12, 056009. PDF, PubMed

Qin W, Wolf P, Liu N, Link S, Smets M, Mastra F, Forné I, Pichler G, Hörl D, Fellinger K, Spada F, Bonapace IM, Imhof A, Harz H and Leonhardt H (2015). DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination. Cell Res., 25, 911-29. PDF, PubMed

Helma J, Cardoso MC, Muyldermans S and Leonhardt H (2015). Nanobodies and recombinant binders in cell biology. J Cell Biol., 209, 633-644. PDF, PubMed

Mulholland CB, Smets M, Schmidtmann E, Leidescher S, Markaki Y, Hofweber M, Qin W, Manzo M, Kremmer E, Thanisch K, Bauer C, Rombaut P, Herzog F, Leonhardt H and Bultmann S (2015). A modular open platform for systematic functional studies under physiological conditions. Nucleic Acids Res., 43, e112. PDF, PubMed

Dahlhoff M, Camera E, Ludovici M, Picardo M, Müller U, Leonhardt H, Zouboulis CC and Schneider MR (2015). EGFR/ERBB receptors differentially modulate sebaceous lipogenesis. FEBS Lett., 589, 1376-82. PubMed

Abendroth C, Hofmeister A, Hake SB, Kamweru PK, Miess E, Dornblut C, Küffner I, Deng W, Leonhardt H, Orthaus S, Hoischen C and Diekmann S (2015).  The CENP-T C-Terminus Is Exclusively Proximal to H3.1 and not to H3.2 or H3.3. Int J Mol Sci, 16, 5839-5863. PDF, PubMed

Borg S, Popp F, Hofmann J, Leonhardt H, Rothbauer U and Schüler D (2015). An intracellular nanotrap redirects proteins and organelles in live bacteria. MBio., 6. PDF, PubMed

Bauer C, Gobel K, Nagaraj N, Colantuoni C, Wang M, Müller U, Kremmer E, Rottach A and Leonhardt H (2015). Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the glycosyltransferase OGT. J Biol Chem., 290, 4801-12. PDF, PubMed


Aschenbrenner D, Pippig DA, Klamecka K, Limmer K, Leonhardt H and Gaub HE (2014). Parallel force assay for protein-protein interactions. PLoS One, 9, e115049. PDF, PubMed

Dahlhoff M, Fröhlich T, Arnold GJ, Müller U, Leonhardt H, Zouboulis CC and Schneider MR (2014). Characterization of the sebocyte lipid droplet proteome reveals novel potential regulators of sebaceous lipogenesis. Exp Cell Res., 332, 146-55. PDF, PubMed

Bizarro J, Charron C, Boulon S, Westman B, Pradet-Balade B, Vandermoere F, Chagot ME, Hallais M, Ahmad Y, Leonhardt H, Lamond A, Manival X, Branlant C, Charpentier B, Verheggen C and Bertrand E (2014). Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control. J. Cell Biol.,  207, 463-80. PDF, PubMed

Song C, Feodorova Y, Guy J, Peichl L, Jost KL, Kimura H, Cardoso MC, Bird A, Leonhardt H, Joffe B and Solovei I (2014). DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution. Epigenetics Chromatin, 7,17. PDF, PubMed

Müller U, Bauer C, Siegl M, Rottach A and Leonhardt H (2014). TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation. Nucleic Acids Res., 42, 8592-604.  PDF, PubMed

Pfaffeneder T, Spada F, Wagner M, Brandmayr C, Laube SK, Eisen D, Truss M, Steinbacher J, Hackner B, Kotljarova O, Schuermann D, Michalakis S, Kosmatchev O, Schiesser S, Steigenberger B, Raddaoui N, Kashiwazaki G, Müller U, Spruijt CG, Vermeulen M, Leonhardt H, Schär P, Müller M and Carell T (2014). Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA. Nat Chem Biol.,10, 574-81. PDF, PubMed

Smeets D,  Markaki Y, Schmid VJ, Kraus F, Tattermusch A, Cerase A, Sterr M, Fiedler S, Demmerle J, Popken J, Leonhardt H, Brockdorff N, Cremer T, Schermelleh L and Cremer M (2014). Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci. Epigenetics Chromatin, 7, 8. PDF, PubMed

De Vos M, El Ramy R, Quénet D, Wolf P, Spada F, Magroun N, Babbio F, Schreiber V, Leonhardt H, Bonapace IM and Dantzer F (2014). Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitinprotein ligase UHRF1 and modulates UHRF1 biological functions. J Biol Chem,  289, 16223-38. PDF, PubMed

Roth S, Rottach A, Lotz-Havla AS, Laux V, Muschaweckh A, Gersting SW, Muntau AC, Hopfner KP, Jin L, Vanness K, Petrini JH, Drexler I, Leonhardt H and Ruland J (2014). Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production. Nat Immunol, 15, 538-45.  PDF, PubMed

Anton T, Bultmann S, Leonhardt H and Markaki Y (2014). Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system. Nucleus, 5, 163-172. PDF, PubMed

Leonhardt H and Hake SB (2014). Histone glutamine methylation afFACTing rDNA transcription. Cell Res., 24, 261-2. PDF, PubMed

Dornblut C, Quinn N, Monajambashi S, Prendergast L, van Vuuren C, Münch S, Deng W, Leonhardt H, Cardoso MC, Hoischen C, Diekmann S and Sullivan KF (2014).  A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle. Open Biol., 4, 130229. PDF, PubMed



Thanisch K, Schneider K, Morbitzer R, Solovei I, Lahaye T, Bultmann S and Leonhardt H (2013). Targeting and tracing of specific DNA sequences with dTALEs in living cells. Nucleic Acids Res., 42, e38. PDF, PubMed

Herce HD, Deng W, Helma J, Leonhardt H and Cardoso MC (2013). Visualization and targeted disruption of protein interactions in living cells. Nat Commun, 4, 2660. PDF, PubMed

Eberhart A, Feodorova Y, Song C, Wanner G, Kiseleva E, Furukawa T, Kimura H, Schotta G, Leonhardt H, Joffe B and Solovei I (2013). Epigenetics of eu- and heterochromatin in inverted and conventional nuclei from mouse retina.  Chromosome Res., 21, 535-54. PDF, PubMed

Bultmann S and Leonhardt H (2013). Fluorescence microscopy-based high-throughput screening for factors involved in gene silencing. Methods Mol Biol, 1042, 237-44. PDF, PubMed

Joffe B, Peichl L, Hendrickson A, Leonhardt H and Solovei I (2013). Diurnality and Nocturnality in Primates: An Analysis from the Rod Photoreceptor Nuclei Perspective. Evol Biol, 41, 1-11. PDF

Liu N, Wang M, Deng W, Schmidt CS, Qin W, Leonhardt H and Spada F (2013). Intrinsic and Extrinsic Connections of Tet3 Dioxygenase with CXXC Zinc Finger Modules. PLoS One, 8, e62755. PDFPubMed

Wolf A, Mantri M, Heim A, Müller U, Fichter E, Mackeen MM, Schermelleh L, Dadie G, Leonhardt H, Vénien-Bryan C, Kessler BM, Schofield CJ and Böttger A (2013) .The poly-serine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization. Biochem J., 453, 357-70. PDFPubMed

Bergink S, Ammon T, Kern M, Schermelleh L, Leonhardt H and Jentsch S (2013). Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction. Nat Cell Biol., 15, 526-32. PDF, PubMed

Hahn M, Dambacher S, Dulev S, Kuznetsova AY, Eck S, Wörz S, Sadic D, Schulte M, Mallm JP, Maiser A, Debs P, von Melchner H, Leonhardt H, Schermelleh L, Rohr K, Rippe K, Storchova Z and Schotta G (2013). Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin. Genes Dev., 27, 859-72. PDF, PubMed 

Schneider K, Fuchs C, Dobay A, Rottach A, Qin W, Wolf P, Álvarez-Castro J, Nalaskowski M, Kremmer E, Schmid V, Leonhardt H and Schermelleh L (2013). Dissection of cell cycle-dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling. Nucleic Acids Res., 41, 4860-4876. PDF, PubMed

Spruijt CG, Gnerlich F, Smits AH, Pfaffeneder T, Jansen PW, Bauer C, Münzel M, Wagner M, Müller M, Khan F, Eberl HC, Mensinga A, Brinkman AB, Lephikov K, Müller U, Walter J, Boelens R, van Ingen H, Leonhardt H, Carell T and Vermeulen M (2013). Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives. Cell, 152, 1146-59. LMU news, PDF, PubMed

Solovei I, Wang AS, Thanisch K, Schmidt CS, Krebs S, Zwerger M, Cohen TV, Devys D, Foisner R, Peichl L, Herrmann H, Blum H, Engelkamp D, Stewart CL, Leonhardt H and Joffe B (2013). LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation. Cell, 152, 584-598. LMU news, PDF, PubMed



Schmidt CS, Bultmann S, Meilinger D, Zacher B, Tresch A, Maier KC, Peter C, Martin DE, Leonhardt H and Spada F (2012). Global DNA Hypomethylation Prevents Consolidation of Differentiation Programs and Allows Reversion to the  Embryonic Stem Cell State. PLoS One, 2012 Dec 27, e52629. PDF, PubMed

Sonnen KF, Schermelleh L, Leonhardt H and Nigg EA (2012). 3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. Biol Open, 1, 965-76. PDF, PubMed

Helma J, Schmidthals K, Lux V, Nüske S, Scholz AM, Kräusslich HG, Rothbauer U and Leonhardt H (2012). Direct and dynamic detection of HIV-1 in living cells. PLoS ONE, 2012 Nov, 7 (11), e50026. PDF, PubMed

Eberhart A, Kimura H, Leonhardt H, Joffe B and Solovei I (2012). Reliable detection of epigenetic histone marks and nuclear proteins in tissue cryosections. Chromosome Res., 20, 849-58. PubMed

Eskat A, Deng W, Hofmeister A, Rudolphi S, Emmerth S, Hellwig D, Ulbricht T, Döring V, Bancroft JM, McAinsh AD, Cardoso MC, Meraldi P, Hoischen C, Leonhardt H and Diekmann S (2012). Step-Wise Assembly, Maturation and Dynamic Behavior of the Human CENP-P/O/R/Q/U Kinetochore Sub-Complex. PLoS ONE, 7, e44717. Epub 2012 Sep 18. PubMed

Zolghadr K, Gregor J, Leonhardt H and Rothbauer U (2012). Case study on live cell apoptosis-assay using lamin-chromobody cell-lines for high-content analysis.  Methods Mol Biol, 911, 569-75. PubMed

Pichler G, Leonhardt H and Rothbauer U (2012). Fluorescent protein specific nanotraps to study protein-protein interactions and histone-tail Peptide binding. Methods Mol Biol, 911, 475-83. PubMed

Gross H, Hennard C, Masouris I, Cassel C, Barth S, Stober-Grässer U, Mamiani A, Moritz B, Ostareck D, Ostareck-Lederer A, Neuenkirchen N, Fischer U, Deng W, Leonhardt H, Noessner E, Kremmer E and Grässer FA (2012). Binding of the Heterogeneous Ribonucleoprotein K (hnRNP K) to the Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) Enhances Viral LMP2A Expression. PLoS ONE, 2012;7, e42106. Epub 2012 Aug 3. PubMed

Arand J, Spieler D, Karius T, Branco MR, Meilinger D, Meissner A, Jenuwein T, Xu G, Leonhardt H, Wolf V and Walter J (2012). In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methlytransferases. PLoS Genet, 2012 June 28 [Epub ahead of print]. PubMed

Hochstatter J, Holzel M, Rohrmoser M, Schermelleh L, Leonhardt H, Keough R, Gonda TJ, Imhof A, Eick D, Langst G, Nemeth A (2012). Myb-binding protein 1a (Mybbp1a) regulates levels and processing of Pre-ribosomal RNA. J. Biol. Chem., 287, 24365-77. PubMed

Pellis M, Pardon E, Zolghadr K, Rothbauer U, Vincke C, Kinne J, Dierynck I, Hertogs K, Leonhardt H, Messens J, Muyldermans S and Conrath K (2012). A bacterial-two-hybrid selection system for one-step isolation of intracellularly functional Nanobodies. Arch Biochem Biophys, 526, 114-23. PubMed

Mikeladze-Dvali T, von Tobel L, Strnad P, Knott G, Leonhardt H, Schermelleh L and Gonczy P (2012). Analysis of centriole elimination during C. elegans oogenesis. Development, 139, 1670-1679. PubMed

Schloßbauer A, Sauer AM, Cauda V, Schmidt A, Engelke H, Rothbauer U, Zolghadr K, Leonhardt H, Bräuchle C and Bein T (2012). Cascaded Photoinduced Drug Delivery to Cells from Multifunctional Core-Shell Mesoporous Silica. Advanced Healthcare Materials, 1: 316-320. PDF, PubMed

Bönisch C, Schneider K, Pünzeler S, Wiedemann SM, Bielmeier C, Bocola M, Eberl HC, Kuegel W, Neumann J, Kremmer E, Leonhardt H, Mann M, Michaelis J, Schermelleh L and Hake SB (2012). H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization. Nucleic Acids Res. 40, 5951-64. PubMed

Bultmann S, Morbitzer R, Schmidt CS, Thanisch K, Spada F, Elsaesser J, Lahaye T and Leonhardt H (2012). Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers. Nucleic Acids Res., 40, 5368-77. PubMed

Kaufmann D, Gassen A, Maiser A, Leonhardt H and Janzen CJ (2012). Regulation and spatial organization of PCNA in Trypanosoma brucei. Biochem Biophysic Res Commun, 419, 698-702 PubMed

Cardoso MC, Schneider K, Martin RM and Leonhardt H (2012). Structure, function and dynamics of nuclear subcompartments. Curr Opin Cell Biol., 24, 79-85. PDF, PubMed PubMed

Zolghadr K, Rothbauer U and Leonhardt H (2012). The Fluorescent Two-Hybrid (F2H) Assay for Direct Analysis of Protein-Protein Interactions in Living Cells. Methods Mol Biol., 812, 275-82. PubMed

Dambacher S, Deng W, Hahn M, Sadic D, Fröhlich J, Nuber A, Hoischen C, Diekmann S, Leonhardt H and Schotta G (2012). CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin. Nucleus, 3, 101-10. PubMed

Lebold T, Schlossbauer A, Schneider K, Schermelleh L, Leonhardt H, Bein T and Bräuchle C (2012). Controlling the mobility of oligonucleotides in the nanochannels of Mesoporous Silica. Adv Funct Mater, 22, 106-112. PDF

Casas-Delucchi CS, van Bemmel JG, Haase S, Herce HD, Nowak D, Meilinger D, Stear JH, Leonhardt H and Cardoso MC (2012). Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin. Nucleic Acids Res., 40, 159-69. PDF, PubMed


Jost KL, Rottach A, Milden M, Bertulat B, Becker A, Wolf P, Sandoval J, Petazzi P, Huertas D, Esteller M, Kremmer E, Leonhardt H and Cardoso MC (2011). Generation and characterization of rat and mouse monoclonal antibodies specific for MeCP2 and their use in X-inactivation studies. PLoS One, 6, e26499. PubMed

Chung I, Leonhardt H and Rippe K (2011). De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation.  J Cell Sci., 124, 3603-18. PDF, PubMed

Qin W, Leonhardt H and Pichler G (2011). Regulation of DNA methyltransferase 1 by interactions and modifications. Nucleus, 2, 392-402. PubMed

Agarwal N, Becker A, Jost KL, Haase S, Thakur BK, Brero A, Hardt T, Kudo S, Leonhardt H and Cardoso MC (2011). MeCP2 Rett mutations affect large scale chromatin organization. Hum Mol Genet., 20, 4187-95. PubMed

Sánchez-Molina S, Mortusewicz O, Bieber B, Auer S, Eckey M, Leonhardt H, Friedl AA and Becker PB (2011). Role of hACF1 in the G2/M damage checkpoint. Nucleic Acids Res., 39, 8445-8456. PubMed

Pollithy A, Romer T, Lang C, Müller FD, Helma J, Leonhardt H, Rothbauer U, and Schüler D (2011). Magnetosome expression of functional camelid antibody fragments (nanobodies) in Magnetospirillum gryphiswaldense. Appl Environ Microbiol, 77, 6165-71. PubMed

Frauer C, Hoffmann T, Bultmann S, Casa V, Cardoso MC, Antes I and Leonhardt H (2011). Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain. PLoS ONE, 6, e21306. PDF, PubMed 

Romer T, Leonhardt H and Rothbauer U (2011). Engineering antibodies and proteins for molecular in vivo imaging. Current Opinion in Biotechnology, Curr Opin Biotechnol, 22, 1-6. PubMed

Frauer C and Leonhardt H (2011). Twists and turns of DNA methylation. PNAS, 108, 8919-20. PubMed.

Pichler G, Wolf P, Schmidt CS, Meilinger D, Schneider K, Frauer C, Fellinger K , Rottach A and Leonhardt H. Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways. J. Cell Biochem., 112, 2585-93. PubMed.

Markaki Y, Gunkel M, Schermelleh L, Beichmanis S, Neumann J, Heidemann M, Leonhardt H, Eick D, Cremer C and Cremer T (2011). Functional Nuclear Organization of Transcription and DNA Replication: A Topographical Marriage between Chromatin Domains and the Interchromatin Compartment. Cold Spring Harb Symp Quant Biol., 69, 2619-25. PubMed.

Konstandin N, Bultmann S, Szwagierczak A, Dufour A, Ksienzyk B, Schneider F, Herold T, Mulaw M, Kakadia PM, Schneider S, Spiekermann K, *Leonhardt H and *Bohlander SK. Genomic 5-hydroxymethylcytosine levels correlate with TET2 and IDH2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia. Leukemia, 25, 1649-52. (*communicating authors). PubMed.

Frauer C, Spada F and Leonhardt H (2011). DNA methylation. In Genome organization and function in the cell nucleus. Rippe, K., ed., Wiley-VCH, Weinheim.

Szwagierczak A, Brachmann A, Schmidt CS, Bultmann S, *Leonhardt H and *Spada F (2011). Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5 hydroxymethylcytosine. Nucl. Acids Res.,  9, 5149-56. (*communicating authors). PubMed.

Casas-Delucchi CS, Brero A, Rahn H-P, Solovei I, Wutz A, Cremer T, Leonhardt H and Cardoso MC. (2011). Histone acetylation controls the inactive X chromosome replication dynamics. Nature Communications, 2, 222, 1-11. PubMed.

Mortusewicz O, Fouquerel E, Amé JC, *Leonhardt H and *Schreiber V. (2011). PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms. Nucl. Acids Res., 39, 5045-56,  (*communicating authors) PubMed.

Frauer C, Rottach A, Meilinger D, Bultmann S, Fellinger K, Hasenöder S, Wang M, Qin W, Söding J, Spada F and Leonhardt H  (2011). Different Binding Properties and Function of CXXC Zinc Finger Domains in Dnmt1 and Tet1. PLoS ONE 6, e16627. PubMed.

Guizetti J, Schermelleh L, Mäntler J, Maar S, Poser I, Leonhardt H, Müller-Reichert T and Gerlich DW (2011). Cortical Constriction During Abscission Involves Helices Of ESCRT-III-Dependent Filaments. Science, 331, 1616-20. PubMed

Qin W, *Leonhardt H and *Spada F (2011). Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1. J. Cell Biochem. 112, 439–444. (*communicating authors). PubMed.



Kirchhofer A, Helma J, Schmidthals K, Frauer C, Cui S, Karcher A, Pellis M, Muyldermans S, Casas Delucchi C, Cardoso MC, *Leonhardt H, *Hopfner KP and *Rothbauer U (2010). Modulation of protein properties in living cells using nanobodies. Nature Struct. Mol. Biol., 17, 133-139. (*communicating authors) PubMed.

Rottach A, Frauer C, Pichler G, Bonapace IM, Spada F and Leonhardt H (2010). The multi-domain protein Np95 connects DNA methylation and histone modification. Nucl. Acids Res. 38, 1796-804. PubMed.

Resemann A, Wunderlich D, Rothbauer U, Warscheid B, Leonhardt H, Fuchser J, Kuhlmann K and Suckau D (2010). Top-down de Novo protein sequencing of a 13.6 kDa camelid single heavy chain antibody by matrix-assisted laser desorption ionization-time-of-flight/time-of-flight mass spectrometry. Anal. Chem., 82, 3283-92. PubMed.

Szwagierczak A, Bultmann S, Schmidt CS, Spada F and Leonhardt H (2010). Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA. Nucl. Acids Res. 38, e181. PubMed.

Wiedemann SM, Mildner SN, Bönisch C, Israel L, Maiser A, Matheisl S, Straub T, Merkl R, Leonhardt H, Kremmer E, Schermelleh E and Hake SB (2010). Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y. J. Cell Biol. 190, 777-791. PubMed.

Leonhardt H (2010). Nanobodies – Kleine Antikörper ganz groß. labor & more, 1.10, 20-24.

Schmidthals K, Helma J, Zolghadr K, Rothbauer U and Leonhardt H (2010). Novel antibody derivatives for proteome and high-content analysis. Anal. Bioanal. Chem. 397, 3203-8. PubMed.

Joffe B, Leonhardt H and Solovei I (2010). Differentiation and large scale spatial organization of the genome. Curr Opin Genet Dev. 20, 562-569. PubMed.

Schermelleh L, Heintzmann R and Leonhardt H (2010). A guide to super-resolution fluorescence microscopy. J. Cell Biol. 190,165-75. PubMed.

Baddeley D, Chagin VO, Schermelleh L, Martin S, Pombo A, Carlton PM, Gahl A, Domaing P, Birk U, Leonhardt H, Cremer C and Cardoso MC (2010). Measurement of replication structures at the nanometer scale using super-resolution light microscopy. Nucl. Acids Res. 38, e8. PubMed.


Frauer C and Leonhardt H (2009). A versatile non-radioactive assay for DNA methyltransferase activity and DNA binding. Nucl. Acids Res., 37, e22. PubMed.

Fellinger K, Rothbauer U, Felle M, Längst G and Leonhardt H (2009). Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain. J. Cell. Biochem., 106, 521-8. PubMed.

Ruzov A, Shorning B, Mortusewicz O, Dunican DS, Leonhardt H, and Meehan R (2009). MBD4 and MLH1 are required for apoptotic induction in xDnmt1-depleted embryos. Development, 136, 2277-86. PubMed.

Meilinger D, Fellinger K, Bultmann S, Rothbauer U, Bonapace IM, Klinkert WE, Spada F and Leonhardt H (2009). Np95 interacts with de novo DNA methyltransferases Dnmt3a and 3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. EMBO Reports, 10, 1259-64. PubMed.

Zolghadr K, Schmidthals K, Helma J, Romer T, Leonhardt H und Rothbauer U (2009). Biomedizinische Forschung und Diagnostik mit fluoreszierenden Nanosonden. Biospektrum, 15, 291-293.


Rothbauer U, Zolghadr K, Muyldermans S, Schepers S, Cardoso MC and Leonhardt H (2008). A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins. Mol. Cell. Proteomics, 7, 282-9. PubMed.

Fellinger K, Leonhardt H and Spada F. (2008). A mutagenesis strategy combining systematic alanine scanning with larger mutations to study protein interactions. Analytical Biochemistry, 373, 176-8. PubMed.

Kuch D, Manetto S, Schermelleh L, Leonhardt H and Carell T (2008). Synthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1. Angew. Chem. (Int. Ed. Engl.), 47, 1515-8. PubMed.

Grünwald D, Martin RM, Buschmann V, Bazett-Jones DP, Leonhardt H, Kubitscheck U and Cardoso MC (2008). Probing Intranuclear Environments at the Single Molecule Level. Biophys. J., 94, 2847-58. PubMed.

Rottach A, Kremmer E, Nowak D, Boisguerin P, Volkmer R, Cardoso MC, Leonhardt H and Rothbauer U (2008). Generation and Characterization of a Rat Monoclonal Antibody Specific for PCNA. Hybridoma, 27, 91-8. PubMed.

Görisch SM, Sporbert A, Grunewald I, Nowak D, Warbrick E, Leonhardt H and Cardoso MC (2008). Uncoupling the replication machinery - replication fork progression in the absence of processive DNA synthesis. Cell Cycle, 7, 1983-90. PubMed.

Papait R, Pistore C, Grazini U, Babbio F, Cogliati S, Pecoraro D, Brino L, Morand AL, Dechampesme AM, Spada F, Leonhardt H, McBlane F, Oudet P and Bonapace I (2008). The PHD of Np95 (mUHRF1) is involved in large-scale reorganization of pericentromeric heterochromatin. Mol. Biol. Cell, 19, 3554-63. PubMed.

Schermelleh L, Carlton PM, Haase S, Shao L, Winoto L, Kner P, Burke,B, Cardoso MC, Agard DA, Gustafsson MG, *Leonhardt H and *Sedat JW (2008). Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy. Science, 320, 1332-6. (*communicating authors). PubMed.

Rottach A, Kremmer E, Nowak D, Leonhardt H and Cardoso MC (2008). Generation and characterization of a rat monoclonal antibody specific for multiple red fluorescent proteins. Hybridoma. 27, 337-43. PubMed.

Zolghadr K, Mortusewicz O, Rothbauer U, Kleinhans R, Göhler H, Wanker E, Cardoso MC and Leonhardt H (2008). A fluorescent two-hybrid (F2H) assay for direct visualization of protein interactions in living cells. Mol. Cell. Proteomics, 7, 2279-87. PubMed.

Trinkle-Mulcahy L, Boulon S, Lam YW, Urcia R, Boisvert FM, Rothbauer U, Leonhardt H and Lamond A (2008). A general strategy for identifying specific protein-protein interaction partners using SILAC MS combined with affinity matrix proteome filtering. J. Cell Biol., 183, 223-39. PubMed.

Mortusewicz O, Roth W, Li N, Cardoso MC, Meisterernst M and Leonhardt H (2008). Recruitment of RNA Polymerase II cofactor PC4 to DNA damage sites. J. Cell Biol., 183, 769-776. PubMed.

Siebrasse JP, Veith R, Dobay A, Leonhardt H, Daneholt B and Kubitscheck U (2008). Discontinuous movement of mRNP particles in nucleoplasmic regions devoid of chromatin. PNAS, 105, 20291-6. PubMed.

Mortusewicz O, Leonhardt H and Cardoso MC (2008). Spatiotemporal dynamics of regulatory protein recruitment at DNA damage sites. J. Cell. Biochem., 104, 1562-9. PubMed.

Schermelleh L, Spada F and Leonhardt H (2008). Visualization and measurement of DNA methyltransferase activity in living cells. Current Protocols in Cell Biology, 22.12.1-22.12.16. In Press. PubMed.

Rothbauer U and Leonhardt H (2008). Connecting biochemistry and cell biology with nanobodies. Zellbiologie aktuell, 34, 9-12.



Martin RM, Tünnemann G, Leonhardt H and Cardoso MC  (2007). Nucleolar marker for living cells. Histochem. Cell Biol., 127, 243-51. PubMed.

Spada F, Haemmer A, Kuch D, Rothbauer U, Schermelleh L, Kremmer E, Carell T, Längst G and Leonhardt  H (2007). DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells. J. Cell Biol., 176, 565-71. PubMed.

Schermelleh L, Haemmer A, Spada F, Rösing N, Meilinger D, Rothbauer U, Cardoso MC and Leonhardt H (2007). Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation. Nucl. Acids Res., 35, 4301-12. PubMed.

Agarwal N, Hardt T, Brero A, Nowak D, Rothbauer U, Becker A, Leonhardt H and Cardoso MC (2007). MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation. Nucl. Acids Res., 35, 5402-8. PubMed.

Martin RM, Görisch SM, Leonhardt H and Cardoso MC (2007). An unexpected link between energy metabolism, calcium, chromatin condensation and cell cycle. Cell Cycle, 6, 2422-4. PubMed.

Mortusewicz O, and Leonhardt H (2007). XRCC1 and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions. BMC Mol Biol., 8:81. PubMed.

Mortusewicz O, Amé JC, Schreiber V and Leonhardt H (2007). Feedback regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells. Nucl. Acids Res., 35, 7665-75. PubMed.

Easwaran HP, Leonhardt H and Cardoso MC (2007). Distribution of DNA replication proteins in Drosophila cells. BMC Cell Biol., 8:42. PubMed.

Mateos-Langerak J, Goetze S, Leonhardt H, Cremer T, van Driel R, and Lanctôt C (2007). Nuclear architecture: Is it important for genome function and can we prove it? J Cell Biochem., 102, 1067-75. PubMed.

Vincke C, Pellis M, Nath Baral T, Stijlemans B, Tillib S, Rothbauer U, Leonhardt H, Conrath K, Magez S, Wernery U, De Baetselier P and Muyldermans S. (2007). Camel antibodies for therapeutic and research applications. Proc. Int. Camel Conf., 2, 71-75. 


Perucca P, Cazzalini O, Mortusewicz O, Necchi D, Savio M, Nardo T, Stivala LA, Leonhardt H, Cardoso MC and Prosperi E (2006). Spatio-temporal dynamics of p21CDKN1A protein recruitment to DNA damage sites and interaction with proliferating cell nuclear antigen. J. Cell Sci., 119, 1517-27. PubMed.

Mortusewicz O, Rothbauer U, Cardoso MC, and Leonhardt H (2006). Differential recruitment of DNA Ligase I and III to DNA repair sites. Nucl. Acids Res., 34, 3523-32. PubMed.

Albiez H, Cremer M, Tiberi C, Vecchio L, Schermelleh L, Dittrich S. Kupper K, Joffe B, Thormeyer T, von Hase J, Yang S, Rohr K, Leonhardt H, Solovei I, Cremer C, Fakan S and Cremer T (2006). Chromatin domains and the interchromatin compartment form structurally defined and functionally interacting nuclear networks. Chromosome Res., 14, 707-33. PubMed.

Rothbauer U, Zolghadr K, Tillib S, Nowak D, Schermelleh L, Gahl A, Backmann N, Conrath K, Muyldermans S, Cardoso MC, and Leonhardt H (2006). Targeting and tracing antigens in live cells with fluorescent nanobodies. Nature Methods, 3, 887-9. PubMed.

Spada F, Rothbauer U, Zolghadr K, Schermelleh L, Leonhardt H (2006). Regulation of DNA methyltransferase 1. Adv. Enzym Regul., 46, 224-34. PubMed.

Brero A, Leonhardt H and Cardoso MC (2006). Replication and translation of epigenetic information. Curr. Top. Microbiol. Immunol., 301, 21-44. PubMed.



Easwaran HP, Leonhardt H and Cardoso MC (2005). Cell cycle markers for live cell analyses. Cell Cycle, 4: 453-455. PubMed.

Grünwald D, Cardoso MC, Leonhardt H and Buschmann V (2005). Diffusion and binding properties investigated by Fluorescence Correlation Spectroscopy (FCS). Curr. Pharm. Biotechnol., 6, 381-6. PubMed.

Mortusewicz O, Schermelleh L, Walter J, Cardoso MC and Leonhardt H (2005). Recruitment of DNA methyltransferase I to DNA repair sites. PNAS, 102, 8905-8909. PubMed.

Brero A, Easwaran HP, Nowak D, Grunewald I, Cremer T, Leonhardt H and Cardoso MC (2005). Methyl CpG binding proteins induce large-scale chromatin reorganization during terminal differentiation. J. Cell Biol., 169, 733-743. PubMed.

Sporbert A, Domaing P, Leonhardt H and Cardoso MC (2005). PCNA acts as a stationary loading platform for transiently interacting Okazaki fragment proteins. Nucl. Acids Res., 33, 3521-3528. PubMed.

Grohmann M, Spada F, Schermelleh L, Alenina N, Bader M, Cardoso MC and Leonhardt H (2005). Restricted mobility of Dnmt1 in early embryos: implications for epigenetic reprogramming. BMC Dev. Biol., 5, 18. PubMed.

Martin RM, Leonhardt H and Cardoso MC (2005). DNA labeling in living cells. Cytometry, 67, 45-52. PubMed.

Schermelleh L, Spada F, Easwaran HP, Zolghadr K, Margot JB, Cardoso MC and Leonhardt H (2005). Trapped in action – direct visualization of Dnmt1 activity in living cells. Nature Methods, 2, 751-756. PubMed

Jambor de Sousa UL, Koss MD, Fillies M, Gahl A, Scheeder MRL, Cardoso MC, Leonhardt H, Geary N, Langhans W and Leonhardt M (2005). CPT 1a over-expression increases long-chain fatty acid oxidation and reduces cell viability with incremental palmitic acid concentration in 293 T cells. Biochem. Biophys. Res. Commun., 338, 757-61. PubMed



Gaudet F, Rideout WM 3rd, Dausman J, Leonhardt H and Jaenisch R (2004). Maintenance of IAP methylation by Dnmt1 in pre and postimplantation embryogenesis. Mol. Cell. Biol., 24, 1640-1648. PubMed

Sadoni N, Cardoso MC, Stelzer EHK, Leonhardt H and Zink D (2004). Stable chromosomal units determine the spatial and temporal organization of DNA replication. J. Cell Sci., 117, 5353-5365. PubMed

Easwaran HP, Schermelleh L, Leonhardt H * and Cardoso MC * (2004). Replication-independent chromatin loading of Dnmt1 during G2 and M phases. EMBO Rep., 5, 1181-1186.   * senior authors PubMed



Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, Gray JW, Leonhardt H and Jaenisch R (2003). Induction of Tumors in Mice by Genomic Hypomethylation. Science, 300: 489-492. [see also Science 300, 442-3] PubeMed

Margot JB, Ehrenhofer-Murray AE and Leonhardt H (2003). Interactions within the DNA methyltransferase family. BMC Molecular Biology, 4, 7. PubMed



Derer W, Easwaran HP, Leonhardt H, and Cardoso MC (2002). A novel approach to induce cell cycle reentry  in terminally differentiated muscle cells. The FASEB J., 16, 132-133. (published online November 29, 2001). PubMed

Quensel C, Krämer J, Cardoso MC, and Leonhardt H (2002). Smoothelin contains  a novel Actin Cytoskeleton  Localization Sequence  with Similarity to Troponin T. J. Cell. Biochem., 85, 403-409. PubMed

Sporbert A, Gahl A, Ankerhold R, Leonhardt H* and Cardoso MC* (2002). DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters. Mol. Cell, 10,  1355-1365. [see also J. Cell Biol.10, 1083]  * senior authors PubMed

Cardoso MC and Leonhardt H (2002). Protein transduction: a novel tool for tissue regeneration. Biol. Chem. 383, 1593-1599. PubMed



Krämer J, Quensel C, Meding J, Cardoso MC, and Leonhardt H (2001). Identification and characterization of novel smoothelin isoforms in vascular smooth muscle. J. Vasc. Res., 38, 120-132. PubMed

Margot JB, Cardoso MC and Leonhardt H (2001). Mammalian DNA methyltransferases show  different subnuclear distribution. J. Cell. Biochem., 83, 373-379. PubMed



Margot JB, Aguirre-Arteta AM, Di Giacco BV, Pradhan S, Roberts RJ, Cardoso MC and Leonhardt H (2000). Structure and function of the mouse DNA methyltransferase gene. Dnmt1 shows a tripartite structure. J. Mol. Biol., 297, 293-300. PubMed

Leonhardt H, Rahn HP, Weinzierl P, Sporbert A, Cremer T, Zink D and Cardoso MC. (2000). Dynamics of DNA replication factories in living cells. J. Cell Biol., 149, 271-280. PubMed

Aguirre-Arteta AM, Grunewald I, Cardoso MC and Leonhardt H (2000). Expression of an alternative Dnmt1 isoform during muscle differentiation. Cell Growth Diff., 11, 551-559. PubMed

Leonhardt H. Die Bedeutung der Epigenetik in der Gen-Medizin. (2000). In Gen-Medizin – Eine Bestandsaufnahme. AM Raem, RW Braun, H Fenger, W Michaelis, S Nikol, SF Winter, eds., p. 111-118, Springer Verlag, Heidelberg,

Leonhardt H, Sporbert A and Cardoso MC (2000). Targeting regulatory factors to intranuclear replication sites. Crit. Rev. Euk. Gene Expr., 12, 127-133. PubMed

Leonhardt H and Cardoso MC (2000). DNA methylation, nuclear structure, gene expression and cancer. J. Cell. Biochem., 35, 78-83. PubMed



Krämer J, Aguirre-Arteta AM, Thiel C, Gross CM, Dietz R, Cardoso MC and Leonhardt H (1999). A novel isoform of the smooth muscle cell differentiation marker smoothelin. J. Mol. Med., 77, 294-298. PubMed.

Engel FB, Hauck L, Cardoso MC, Leonhardt H, Dietz R and von Harsdorf R (1999). A mammalian myocardial cell-free system to study cell cycle re-entry in terminally differentiated cardiomyocytes. Circ. Res., 85, 294-301. PubMed.

Derer W, Easwaran HP, Knopf CW, Leonhardt H and Cardoso MC (1999). Direct protein transfer to terminally differentiated muscle cells. J. Mol. Med., 77, 609-613. PubMed.

Cardoso MC and Leonhardt H (1999). DNA methyltransferase is actively retained in the cytoplasm during early development. J. Cell Biol., 147, 25-32. PubMed.

Cardoso MC and Leonhardt H (1999). Differentiation, development and programmed cell death. In The Molecular Basis of Cell Cycle and Growth Control. G. Stein, R. Baserga, D. Denhardt, A. Giordano, eds.,  305-347, John Wiley & Sons, New York.

Cardoso MC, Sporbert A and Leonhardt H (1999). Structure and function in the nucleus: Subnuclear trafficking of DNA replication factors. J. Cell. Biochem., 32/33, 15-23. PubMed.

Leonhardt H, Rahn HP and Cardoso MC (1999). Functional links between nuclear structure, gene expression, DNA replication and methylation. Crit. Rev. Euk. Gene Expr., 9, 345-351. PubMed.



Gaudet F, Talbot D, Leonhardt H and Jaenisch R (1998). A short DNA methyltransferase isoform restores methylation in vivo. J. Biol. Chem., 273, 32725-32729. PubMed.

Leonhardt H, Rahn HP and Cardoso MC (1998). Intranuclear targeting of DNA replication factors. J. Cell. Biochem.,  30/31, 243-249. PubMed.

Cardoso MC and Leonhardt H (1998). Protein targeting to subnuclear higher order structures: a new level of regulation and coordination of nuclear processes. J. Cell. Biochem., 70, 222-230. PubMed.


Cardoso MC, Joseph C, Rahn HP, Reusch R, Nadal-Ginard B and Leonhardt H (1997). Mapping and use of a sequence that targets DNA ligase I to sites of DNA replication in vivo. J. Cell Biol., 139, 579-587. PubMed.



Tucker KL, Talbot D, Lee MA, Leonhardt H and Jaenisch R (1996). Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase mini-gene. PNAS, 93, 12920-12925. PubMed.



Cardoso MC and Leonhardt H (1995). Immunofluorescence techniques in cell cycle studies. In Cell Cycle: Materials and Methods. M. Pagano, ed., p. 15-28, Springer Verlag, Heidelberg.

Leonhardt H and Cardoso MC (1995). Targeting and association of proteins with functional domains in the nucleus: The insoluble solution. In Structural and Functional Organization of the Nuclear Matrix. R. Berezney and K. W. Jeon, eds., International Review of Cytology, vol. 162B, p. 303-335, Academic Press, San Diego. PubMed.


Cardoso MC, Leonhardt H and Nadal-Ginard B (1993). Reversal of terminal differentiation and control of DNA replication: Cyclin A and cdk2 specifically localize at subnuclear sites of DNA replication. Cell, 74, 979-992. PubMed.

Leonhardt H and Bestor TH (1993). Structure, function and regulation of mammalian DNA methyltransferase. In DNA Methylation: Molecular Biology and Biological Significance. J.-P. Jost and H.P. Saluz, eds., p. 109-119, Birkhäuser Verlag, Basel.


Leonhardt H, Page AW, Weier U and Bestor TH (1992). A targeting sequence directs DNA Methyltransferase to sites of DNA replication in mammalian nuclei. Cell, 71, 865-873. [see also Nature, 361, 684-5] PubMed.


Leonhardt H and Alonso JC (1991). Parameters affecting plasmid stability in Bacillus subtilis. Gene, 103, 107-111. PubMed.

Leonhardt H, Lurz R and Alonso JC (1991). Physical and biochemical characterization of recombination-dependent synthesis of linear plasmid multimers in Bacillus subtilis. Nucl. Acids Res., 19, 497-503. PubMed.

Czank A, Häuselmann R, Page AW, Leonhardt H, Bestor TH, Schaffner W and Hergersberg M (1991). Expression in mammalian cells of a cloned gene encoding murine DNA methyltransferase. Gene, 109, 259-263. PubMed.



Leonhardt H (1990). Identification of a low copy number mutation within the pUB110 replicon and its effect on plasmid stability in Bacillus subtilis. Gene, 94,121-124. PubMed.


Leonhardt H and Alonso JC (1988). Construction of a shuttle vector for inducible gene expression in Escherichia coli and Bacillus subtilis. J. Gen. Microbiol., 134, 605-9. PubMed.

Leonhardt H and Alonso JC (1988). S1 mapping of the pC194 encoded chloramphenicol acetyltransferase gene in Bacillus subtilis. Nucl. Acids Res., 16, 1618. PubMed.

Alonso JC, Leonhardt H and Stiege CA (1988). Functional analysis of the leading strand replication origin of plasmid pUB110 in Bacillus subtilis. Nucl. Acids Res., 16, 9127-9145. PubMed.