Human Biology & BioImaging

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Chromatin inversion is a natural state of compartment organization

Utilizing the Hi-C method, we have shown that principles of genome folding are similar between inverted and conventional nuclei. The complementary microscopy and Hi-C data allowed us to build up minimal heteropolymer models of chromosomes within inverted and conventional nuclei. Computer simulations showed that interactions between heterochromatic genomic regions are essential for the nuclear compartmentalization, whereas interactions between euchromatic genomic regions are dispensable, and that inversion constitutes the natural state of compartment organization perturbed by lamina-chromatin interactions in conventional nuclei (Falk et al. 2019, PubMed