Human Biology & BioImaging

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Conventional nuclear organization is established and maintained by tethering heterochromatin to the nuclear envelope by two major mechanisms

We have identified two tethers of peripheral heterochromatin, LBR- and lamin A/C dependent tethers. The tethers are used sequentially during cell differentiation and development and have opposite effects on the expression of tissue specific genes. Absence of both tethers leads to nuclear inversion. Correspondingly, differentiated rods of nocturnal mammals express neither LBR, no lamin A/C and have inverted nuclei. Rods of diurnal mammals express one of these proteins and thus have conventional nuclei (Solovei et al. 2013, PubMed; Joffe et al. 2014, Evol Biol; Thanisch et al. 2017, PubMed)